Depression and Inflammation study
This study investigated inflammatory predictors of depression by evaluating the effects of immunotherapy treatment for chronic hepatitis C viral infection. Often, immunotherapies such as interferon-alpha (and ribavirin), which were commonly used in the past, also increased the likelihood of developing depression in about 30% of those receiving treatment. Our research team investigated how clinical and biological factors are associated with development of interferon-alpha induced depression. We found that patients who developed IFN-α-induced depression had an increased biological sensitivity to IFN-α, as shown by larger gene expression changes related to inflammation, neuroplasticity and oxidative stress-related pathways.
Recruitment: Closed
Research/Analysis: Complete
Publications:
